Patient-specific biology
Human pluripotent stem cells are differentiated into kidney structures that help model development, inherited disease, injury, and repair.
Morizane Lab
Building human kidney models that connect discovery, disease, and therapy.
The Morizane Lab develops stem-cell-derived kidney organoids, vascularized organoid-on-chip systems, and automated culture workflows to study human kidney development, injury, genetic disease, and preclinical therapeutic response.
Organoid platforms
Kidney organoids can be adapted for imaging, drug response, toxicology, organ-on-chip, and biofabrication workflows.
Translation
The work is positioned for sponsored research with academic, clinical, biotechnology, and pharmaceutical partners.
For patients and families
Why kidney organoids matter
Many kidney diseases are difficult to study directly in patients, and animal or two-dimensional cell models do not always capture human kidney biology. Kidney organoids provide a human, three-dimensional system for asking earlier, safer questions about disease mechanisms and candidate treatments while reducing dependence on animal-only models.
Public-facing message
Our goal is to create better human kidney models so that future therapies can be tested with greater biological relevance before they reach patients.
Lab and training
PI background, mentoring record, postdoctoral opportunities, student projects, and visiting positions.
Research overview
Kidney organoid generation, disease modeling, injury assays, and bioengineered tissue directions.
Industry collaboration
Use cases for drug screening, toxicology, gene therapy safety, imaging, and organoid-on-chip studies.
Publication highlights
Plain-language summaries of selected papers and how they support the lab's scientific direction.
Support the mission
Philanthropy can help move translational studies forward when conventional mechanisms are difficult to align.